Much is being learned about various biological or neuro-biological implications for those diagnosed with Borderline Personality Disorder. Whatever one believes about recent scientific exploration, the jury is still out in terms of proven and agreed upon conclusions. Invalidation in one’s environment, growing up, as a child remains a strong common denominator in the reported experience of most, if not all, who have Borderline Personality Disorder. Invalidation in Borderline Personality Disorder remains a central ingredient in so much of the relational difficulty for those with BPD and their loved ones.